Identification of synthetic inducers and inhibitors of the quorum-sensing regulator LasR in Pseudomonas aeruginosa by high-throughput screening.
نویسندگان
چکیده
We report the screening of 16,000 synthetic compounds for induction and inhibition of quorum sensing in a Pseudomonas putida N-acylated l-homoserine lactone (AHL) sensor strain engineered with the LasR transcriptional activator. LasR controls virulence gene expression in the opportunistic pathogen Pseudomonas aeruginosa and is of significant interest as a therapeutic target. Nine compounds that inhibit and 14 compounds that induce LasR activity were identified in our high-throughput screen.
منابع مشابه
Novel Pseudomonas aeruginosa quorum-sensing inhibitors identified in an ultra-high-throughput screen.
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ورودعنوان ژورنال:
- Applied and environmental microbiology
دوره 76 24 شماره
صفحات -
تاریخ انتشار 2010